| Isabela to Enterprise (Nevada) | 3,160.99 mi (5,087.13 km) |
| Isabela to Enumclaw (Washington) | 3,657.70 mi (5,886.50 km) |
| Isabela to Ephrata (Pennsylvania) | 1,594.14 mi (2,565.53 km) |
| Isabela to Erie (Colorado) | 2,701.20 mi (4,347.15 km) |
| Isabela to Erie (Pennsylvania) | 1,802.97 mi (2,901.60 km) |
| Isabela to Erlanger (Kentucky) | 1,765.00 mi (2,840.49 km) |
| Isabela to Escanaba (Michigan) | 2,204.99 mi (3,548.58 km) |
| Isabela to Escondido (California) | 3,240.07 mi (5,214.39 km) |
| Isabela to Española (New Mexico) | 2,661.87 mi (4,283.86 km) |
| Isabela to Essex (Maryland) | 1,543.95 mi (2,484.75 km) |
| Isabela to Essex Junction (Vermont) | 1,830.02 mi (2,945.13 km) |
| Isabela to Estelle (Louisiana) | 1,647.76 mi (2,651.81 km) |
| Isabela to Estero (Florida) | 1,089.49 mi (1,753.36 km) |
| Isabela to Euclid (Ohio) | 1,809.87 mi (2,912.71 km) |
| Isabela to Eufaula (Alabama) | 1,459.88 mi (2,349.44 km) |
