| Isabela to Lewiston (Maine) | 1,777.65 mi (2,860.85 km) |
| Isabela to Lewisville (North Carolina) | 1,464.74 mi (2,357.27 km) |
| Isabela to Lewisville (Texas) | 2,106.59 mi (3,390.23 km) |
| Isabela to Lexington (Kentucky) | 1,710.75 mi (2,753.19 km) |
| Isabela to Lexington (Nebraska) | 2,471.45 mi (3,977.41 km) |
| Isabela to Lexington (North Carolina) | 1,443.17 mi (2,322.56 km) |
| Isabela to Lexington (South Carolina) | 1,382.26 mi (2,224.54 km) |
| Isabela to Lexington Park (Maryland) | 1,478.00 mi (2,378.61 km) |
| Isabela to Liberal (Kansas) | 2,416.96 mi (3,889.73 km) |
| Isabela to Liberty (Missouri) | 2,175.12 mi (3,500.52 km) |
| Isabela to Liberty Lake (Washington) | 3,446.53 mi (5,546.65 km) |
| Isabela to Liberty Triangle (Florida) | 1,205.06 mi (1,939.36 km) |
| Isabela to Libertyville (Illinois) | 2,051.61 mi (3,301.75 km) |
| Isabela to Lighthouse Point (Florida) | 991.83 mi (1,596.20 km) |
| Isabela to Lilburn (Georgia) | 1,497.74 mi (2,410.39 km) |
