| Isabela to McKeesport (Pennsylvania) | 1,690.65 mi (2,720.84 km) |
| Isabela to McKinleyville (California) | 3,683.85 mi (5,928.59 km) |
| Isabela to McKinney (Texas) | 2,093.56 mi (3,369.26 km) |
| Isabela to McLean (Virginia) | 1,538.62 mi (2,476.16 km) |
| Isabela to McMinnville (Oregon) | 3,685.10 mi (5,930.59 km) |
| Isabela to McMinnville (Tennessee) | 1,649.64 mi (2,654.84 km) |
| Isabela to McNair (Virginia) | 1,544.30 mi (2,485.30 km) |
| Isabela to McPherson (Kansas) | 2,294.65 mi (3,692.88 km) |
| Isabela to Mead Valley (California) | 3,256.94 mi (5,241.53 km) |
| Isabela to Meadow Woods (Florida) | 1,133.97 mi (1,824.95 km) |
| Isabela to Meadowbrook (Virginia) | 1,452.79 mi (2,338.04 km) |
| Isabela to Meadville (Pennsylvania) | 1,776.60 mi (2,859.16 km) |
| Isabela to Mebane (North Carolina) | 1,426.13 mi (2,295.13 km) |
| Isabela to Mechanicsville (Virginia) | 1,461.65 mi (2,352.29 km) |
| Isabela to Medford (Massachusetts) | 1,670.30 mi (2,688.09 km) |
