| Isabela to Odessa (Texas) | 2,380.36 mi (3,830.81 km) |
| Isabela to Ogden (Utah) | 3,070.89 mi (4,942.12 km) |
| Isabela to Oildale (California) | 3,367.07 mi (5,418.77 km) |
| Isabela to Ojus (Florida) | 984.73 mi (1,584.76 km) |
| Isabela to Okemos (Michigan) | 1,957.53 mi (3,150.34 km) |
| Isabela to Oklahoma City (Oklahoma) | 2,198.98 mi (3,538.92 km) |
| Isabela to Okmulgee (Oklahoma) | 2,126.56 mi (3,422.36 km) |
| Isabela to Olathe (Kansas) | 2,179.87 mi (3,508.16 km) |
| Isabela to Old Jamestown (Missouri) | 1,979.28 mi (3,185.34 km) |
| Isabela to Oldsmar (Florida) | 1,190.54 mi (1,916.00 km) |
| Isabela to Olean (New York) | 1,762.00 mi (2,835.66 km) |
| Isabela to Olive Branch (Mississippi) | 1,802.23 mi (2,900.42 km) |
| Isabela to Olivehurst (California) | 3,534.81 mi (5,688.73 km) |
| Isabela to Olney (Maryland) | 1,548.33 mi (2,491.80 km) |
| Isabela to Olympia (Washington) | 3,696.77 mi (5,949.37 km) |
