| Isabela to Olympia Heights (Florida) | 986.88 mi (1,588.22 km) |
| Isabela to Omaha (Nebraska) | 2,324.22 mi (3,740.48 km) |
| Isabela to On Top of the World Designated Place (Florida) | 1,209.59 mi (1,946.65 km) |
| Isabela to Onalaska (Wisconsin) | 2,245.28 mi (3,613.43 km) |
| Isabela to Oneida (New York) | 1,771.50 mi (2,850.96 km) |
| Isabela to Oneonta (New York) | 1,721.10 mi (2,769.84 km) |
| Isabela to Ontario (California) | 3,276.69 mi (5,273.32 km) |
| Isabela to Ontario (Oregon) | 3,368.91 mi (5,421.74 km) |
| Isabela to Opa-locka (Florida) | 988.00 mi (1,590.03 km) |
| Isabela to Opelika (Alabama) | 1,500.86 mi (2,415.40 km) |
| Isabela to Opelousas (Louisiana) | 1,774.97 mi (2,856.54 km) |
| Isabela to Orange (California) | 3,287.39 mi (5,290.55 km) |
| Isabela to Orange (Texas) | 1,858.76 mi (2,991.39 km) |
| Isabela to Orange City (Florida) | 1,153.28 mi (1,856.02 km) |
| Isabela to Orangeburg (South Carolina) | 1,343.34 mi (2,161.89 km) |
