| Isabela to Reidsville (North Carolina) | 1,453.18 mi (2,338.67 km) |
| Isabela to Reisterstown (Maryland) | 1,561.73 mi (2,513.36 km) |
| Isabela to Rendon (Texas) | 2,109.07 mi (3,394.22 km) |
| Isabela to Reno (Nevada) | 3,449.08 mi (5,550.76 km) |
| Isabela to Renton (Washington) | 3,671.31 mi (5,908.41 km) |
| Isabela to Republic (Missouri) | 2,052.76 mi (3,303.60 km) |
| Isabela to Reston (Virginia) | 1,542.62 mi (2,482.61 km) |
| Isabela to Revere (Massachusetts) | 1,669.12 mi (2,686.19 km) |
| Isabela to Rexburg (Idaho) | 3,118.48 mi (5,018.71 km) |
| Isabela to Reynoldsburg (Ohio) | 1,755.23 mi (2,824.77 km) |
| Isabela to Rialto (California) | 3,264.88 mi (5,254.31 km) |
| Isabela to Richardson (Texas) | 2,090.04 mi (3,363.60 km) |
| Isabela to Richfield (Minnesota) | 2,366.87 mi (3,809.11 km) |
| Isabela to Richfield (Wisconsin) | 2,109.21 mi (3,394.45 km) |
| Isabela to Richland (Washington) | 3,518.42 mi (5,662.35 km) |
