| Isabela to Sanford (Maine) | 1,735.86 mi (2,793.60 km) |
| Isabela to Sanford (North Carolina) | 1,389.25 mi (2,235.78 km) |
| Isabela to Sanger (California) | 3,406.20 mi (5,481.75 km) |
| Isabela to Santa Ana (California) | 3,290.39 mi (5,295.38 km) |
| Isabela to Santa Barbara (California) | 3,399.40 mi (5,470.80 km) |
| Isabela to Santa Clara (California) | 3,543.40 mi (5,702.55 km) |
| Isabela to Santa Clara (Oregon) | 3,668.55 mi (5,903.96 km) |
| Isabela to Santa Clarita (California) | 3,329.86 mi (5,358.90 km) |
| Isabela to Santa Cruz (California) | 3,544.45 mi (5,704.24 km) |
| Isabela to Santa Fe (New Mexico) | 2,650.57 mi (4,265.69 km) |
| Isabela to Santa Fe (Texas) | 1,919.42 mi (3,089.01 km) |
| Isabela to Santa Fe Springs (California) | 3,301.98 mi (5,314.02 km) |
| Isabela to Santa Maria (California) | 3,443.23 mi (5,541.35 km) |
| Isabela to Santa Monica (California) | 3,326.43 mi (5,353.38 km) |
| Isabela to Santa Paula (California) | 3,361.77 mi (5,410.25 km) |
