| Isabela to Santa Rosa (California) | 3,591.19 mi (5,779.46 km) |
| Isabela to Santaquin (Utah) | 3,037.64 mi (4,888.61 km) |
| Isabela to Santee (California) | 3,233.29 mi (5,203.49 km) |
| Isabela to Sapulpa (Oklahoma) | 2,143.38 mi (3,449.44 km) |
| Isabela to Saraland (Alabama) | 1,569.97 mi (2,526.62 km) |
| Isabela to Sarasota (Florida) | 1,159.65 mi (1,866.28 km) |
| Isabela to Sarasota Springs (Florida) | 1,154.96 mi (1,858.73 km) |
| Isabela to Saratoga (California) | 3,545.92 mi (5,706.61 km) |
| Isabela to Saratoga Springs (New York) | 1,742.74 mi (2,804.67 km) |
| Isabela to Saratoga Springs (Utah) | 3,050.91 mi (4,909.97 km) |
| Isabela to Sartell (Minnesota) | 2,435.04 mi (3,918.81 km) |
| Isabela to Satellite Beach (Florida) | 1,089.10 mi (1,752.73 km) |
| Isabela to Sauk Rapids (Minnesota) | 2,431.67 mi (3,913.39 km) |
| Isabela to Sault Ste. Marie (Michigan) | 2,170.84 mi (3,493.63 km) |
| Isabela to Savage (Minnesota) | 2,364.22 mi (3,804.84 km) |
