| Isabela to Scottsboro (Alabama) | 1,614.97 mi (2,599.04 km) |
| Isabela to Scottsdale (Arizona) | 2,946.98 mi (4,742.71 km) |
| Isabela to Scranton (Pennsylvania) | 1,662.84 mi (2,676.09 km) |
| Isabela to Seabrook (Maryland) | 1,532.84 mi (2,466.87 km) |
| Isabela to Seabrook (Texas) | 1,918.75 mi (3,087.93 km) |
| Isabela to Seaford (New York) | 1,579.08 mi (2,541.29 km) |
| Isabela to Seagoville (Texas) | 2,073.27 mi (3,336.60 km) |
| Isabela to Seal Beach (California) | 3,301.35 mi (5,313.00 km) |
| Isabela to Searcy (Arkansas) | 1,902.97 mi (3,062.54 km) |
| Isabela to Seaside (California) | 3,530.33 mi (5,681.52 km) |
| Isabela to SeaTac (Washington) | 3,675.63 mi (5,915.35 km) |
| Isabela to Seattle (Washington) | 3,679.61 mi (5,921.76 km) |
| Isabela to Sebastian (Florida) | 1,067.57 mi (1,718.08 km) |
| Isabela to Sebring (Florida) | 1,106.34 mi (1,780.48 km) |
| Isabela to Secaucus (New Jersey) | 1,595.16 mi (2,567.17 km) |
