| Isabela to Security-Widefield (Colorado) | 2,652.23 mi (4,268.35 km) |
| Isabela to Sedalia (Missouri) | 2,101.71 mi (3,382.38 km) |
| Isabela to Sedro-Woolley (Washington) | 3,690.04 mi (5,938.54 km) |
| Isabela to Seguin (Texas) | 2,089.24 mi (3,362.31 km) |
| Isabela to Selden (New York) | 1,586.46 mi (2,553.16 km) |
| Isabela to Selma (Alabama) | 1,570.77 mi (2,527.91 km) |
| Isabela to Selma (California) | 3,408.29 mi (5,485.11 km) |
| Isabela to Selma (Texas) | 2,109.32 mi (3,394.62 km) |
| Isabela to Seminole (Florida) | 1,189.46 mi (1,914.24 km) |
| Isabela to Seven Hills (Ohio) | 1,802.02 mi (2,900.06 km) |
| Isabela to Seven Oaks (South Carolina) | 1,382.25 mi (2,224.52 km) |
| Isabela to Severn (Maryland) | 1,539.04 mi (2,476.84 km) |
| Isabela to Severna Park (Maryland) | 1,533.15 mi (2,467.36 km) |
| Isabela to Sevierville (Tennessee) | 1,568.93 mi (2,524.94 km) |
| Isabela to Seymour (Indiana) | 1,809.41 mi (2,911.96 km) |
