| Isabela to Seymour (Tennessee) | 1,576.31 mi (2,536.83 km) |
| Isabela to Shady Hills (Florida) | 1,196.66 mi (1,925.84 km) |
| Isabela to Shafter (California) | 3,376.99 mi (5,434.73 km) |
| Isabela to Shaker Heights (Ohio) | 1,803.99 mi (2,903.24 km) |
| Isabela to Shakopee (Minnesota) | 2,369.32 mi (3,813.05 km) |
| Isabela to Sharon (Pennsylvania) | 1,761.17 mi (2,834.33 km) |
| Isabela to Sharonville (Ohio) | 1,772.78 mi (2,853.02 km) |
| Isabela to Shasta Lake (California) | 3,592.85 mi (5,782.14 km) |
| Isabela to Shawnee (Kansas) | 2,184.21 mi (3,515.15 km) |
| Isabela to Shawnee (Oklahoma) | 2,167.56 mi (3,488.36 km) |
| Isabela to Sheboygan (Wisconsin) | 2,118.08 mi (3,408.72 km) |
| Isabela to Shelby (North Carolina) | 1,461.43 mi (2,351.94 km) |
| Isabela to Shelbyville (Indiana) | 1,834.73 mi (2,952.72 km) |
| Isabela to Shelbyville (Kentucky) | 1,747.74 mi (2,812.72 km) |
| Isabela to Shelbyville (Tennessee) | 1,669.95 mi (2,687.53 km) |
