| Isabela to Silver Firs (Washington) | 3,675.63 mi (5,915.35 km) |
| Isabela to Silver Spring (Maryland) | 1,538.21 mi (2,475.50 km) |
| Isabela to Silver Springs Shores (Florida) | 1,196.29 mi (1,925.25 km) |
| Isabela to Silverdale (Washington) | 3,696.56 mi (5,949.04 km) |
| Isabela to Silverton (Oregon) | 3,662.69 mi (5,894.53 km) |
| Isabela to Simi Valley (California) | 3,343.23 mi (5,380.40 km) |
| Isabela to Simpsonville (South Carolina) | 1,460.01 mi (2,349.65 km) |
| Isabela to Sioux City (Iowa) | 2,386.64 mi (3,840.92 km) |
| Isabela to Sioux Falls (South Dakota) | 2,442.36 mi (3,930.59 km) |
| Isabela to Skokie (Illinois) | 2,031.01 mi (3,268.60 km) |
| Isabela to Sleepy Hollow (New York) | 1,612.89 mi (2,595.69 km) |
| Isabela to Slidell (Louisiana) | 1,642.68 mi (2,643.64 km) |
| Isabela to Smithfield (North Carolina) | 1,364.36 mi (2,195.73 km) |
| Isabela to Smithfield (Utah) | 3,076.34 mi (4,950.90 km) |
| Isabela to Smithville (Missouri) | 2,187.86 mi (3,521.02 km) |
