| Isabela to Smyrna (Delaware) | 1,525.85 mi (2,455.61 km) |
| Isabela to Smyrna (Georgia) | 1,513.14 mi (2,435.17 km) |
| Isabela to Smyrna (Tennessee) | 1,694.01 mi (2,726.25 km) |
| Isabela to Snellville (Georgia) | 1,490.49 mi (2,398.70 km) |
| Isabela to Snoqualmie (Washington) | 3,656.23 mi (5,884.13 km) |
| Isabela to Snyder (Texas) | 2,315.02 mi (3,725.67 km) |
| Isabela to Socastee (South Carolina) | 1,283.92 mi (2,066.27 km) |
| Isabela to Socorro (Texas) | 2,601.25 mi (4,186.30 km) |
| Isabela to Soddy-Daisy (Tennessee) | 1,604.39 mi (2,582.02 km) |
| Isabela to Solana Beach (California) | 3,249.87 mi (5,230.16 km) |
| Isabela to Soledad (California) | 3,502.79 mi (5,637.20 km) |
| Isabela to Solon (Ohio) | 1,795.81 mi (2,890.08 km) |
| Isabela to Somers Point (New Jersey) | 1,508.24 mi (2,427.28 km) |
| Isabela to Somerset (Kentucky) | 1,668.51 mi (2,685.21 km) |
| Isabela to Somerset (New Jersey) | 1,584.23 mi (2,549.57 km) |
