| Isabela to Somersworth (New Hampshire) | 1,725.14 mi (2,776.34 km) |
| Isabela to Somerton (Arizona) | 3,099.35 mi (4,987.93 km) |
| Isabela to Somerville (Massachusetts) | 1,668.02 mi (2,684.41 km) |
| Isabela to Somerville (New Jersey) | 1,590.05 mi (2,558.94 km) |
| Isabela to Sonoma (California) | 3,576.74 mi (5,756.20 km) |
| Isabela to Soquel (California) | 3,539.83 mi (5,696.81 km) |
| Isabela to South Bend (Indiana) | 1,961.85 mi (3,157.29 km) |
| Isabela to South Bradenton (Florida) | 1,165.81 mi (1,876.18 km) |
| Isabela to South Burlington (Vermont) | 1,829.33 mi (2,944.02 km) |
| Isabela to South Charleston (West Virginia) | 1,631.23 mi (2,625.22 km) |
| Isabela to South Daytona (Florida) | 1,148.91 mi (1,849.00 km) |
| Isabela to South El Monte (California) | 3,301.94 mi (5,313.96 km) |
| Isabela to South Elgin (Illinois) | 2,049.05 mi (3,297.62 km) |
| Isabela to South Euclid (Ohio) | 1,806.17 mi (2,906.75 km) |
| Isabela to South Farmingdale (New York) | 1,581.74 mi (2,545.56 km) |
