| Isabela to Southern Pines (North Carolina) | 1,380.29 mi (2,221.37 km) |
| Isabela to Southfield (Michigan) | 1,910.40 mi (3,074.49 km) |
| Isabela to Southgate (Michigan) | 1,893.41 mi (3,047.14 km) |
| Isabela to Southlake (Texas) | 2,113.49 mi (3,401.34 km) |
| Isabela to Spanaway (Washington) | 3,675.92 mi (5,915.82 km) |
| Isabela to Spanish Fork (Utah) | 3,032.48 mi (4,880.30 km) |
| Isabela to Spanish Lake (Missouri) | 1,973.84 mi (3,176.59 km) |
| Isabela to Spanish Springs (Nevada) | 3,440.86 mi (5,537.52 km) |
| Isabela to Sparks (Nevada) | 3,442.39 mi (5,539.99 km) |
| Isabela to Spartanburg (South Carolina) | 1,457.99 mi (2,346.40 km) |
| Isabela to Spearfish (South Dakota) | 2,775.70 mi (4,467.06 km) |
| Isabela to Speedway (Indiana) | 1,864.83 mi (3,001.15 km) |
| Isabela to Spencer (Iowa) | 2,362.48 mi (3,802.04 km) |
| Isabela to Spokane (Washington) | 3,461.08 mi (5,570.08 km) |
| Isabela to Spokane Valley (Washington) | 3,452.20 mi (5,555.78 km) |
