| Isernia to Santeramo in Colle | 142.59 mi (229.48 km) |
| Isernia to Santo Stefano di Magra | 281.38 mi (452.84 km) |
| Isernia to Santo Stino di Livenza | 295.78 mi (476.02 km) |
| Isernia to Sarezzo | 344.88 mi (555.03 km) |
| Isernia to Sarno | 57.74 mi (92.93 km) |
| Isernia to Saronno | 380.60 mi (612.52 km) |
| Isernia to Sarzana | 277.57 mi (446.70 km) |
| Isernia to Sassari | 301.55 mi (485.29 km) |
| Isernia to Sasso Marconi | 245.27 mi (394.72 km) |
| Isernia to Sassuolo | 268.09 mi (431.45 km) |
| Isernia to Sava | 192.33 mi (309.53 km) |
| Isernia to Saviano | 49.54 mi (79.73 km) |
| Isernia to Savigliano | 393.90 mi (633.93 km) |
| Isernia to Savignano sul Panaro | 256.52 mi (412.83 km) |
| Isernia to Savignano sul Rubicone | 195.53 mi (314.67 km) |
