| Isernia to Somma Lombardo | 395.04 mi (635.76 km) |
| Isernia to Somma Vesuviana | 51.49 mi (82.86 km) |
| Isernia to Sommacampagna | 312.49 mi (502.91 km) |
| Isernia to Sona | 314.85 mi (506.70 km) |
| Isernia to Sondrio | 383.16 mi (616.63 km) |
| Isernia to Sora | 33.11 mi (53.28 km) |
| Isernia to Sorbolo | 294.30 mi (473.63 km) |
| Isernia to Soresina | 336.22 mi (541.09 km) |
| Isernia to Sorisole | 366.04 mi (589.08 km) |
| Isernia to Sorrento | 67.73 mi (108.99 km) |
| Isernia to Sorso | 299.52 mi (482.02 km) |
| Isernia to Sortino | 309.42 mi (497.96 km) |
| Isernia to Soverato Marina | 235.73 mi (379.37 km) |
| Isernia to Sovicille | 192.28 mi (309.44 km) |
| Isernia to Spello | 124.85 mi (200.93 km) |
