| Isernia to Schijndel | 807.04 mi (1,298.80 km) |
| Isernia to Schinnen | 758.08 mi (1,220.02 km) |
| Isernia to Schoonhoven | 840.19 mi (1,352.16 km) |
| Isernia to Simpelveld | 748.97 mi (1,205.36 km) |
| Isernia to Sint Anthonis | 796.91 mi (1,282.50 km) |
| Isernia to Sint Willebrord | 824.50 mi (1,326.90 km) |
| Isernia to Sint-Michielsgestel | 810.37 mi (1,304.16 km) |
| Isernia to Sint-Oedenrode | 803.35 mi (1,292.86 km) |
| Isernia to Sittard | 761.33 mi (1,225.24 km) |
| Isernia to Sliedrecht | 834.79 mi (1,343.46 km) |
| Isernia to Slochteren | 873.47 mi (1,405.71 km) |
| Isernia to Sluis | 844.63 mi (1,359.31 km) |
| Isernia to Sneek | 884.63 mi (1,423.67 km) |
| Isernia to Soest | 842.70 mi (1,356.20 km) |
| Isernia to Someren | 786.85 mi (1,266.31 km) |
