| Isernia to Santiago do Cacem | 1,238.60 mi (1,993.33 km) |
| Isernia to Santo Andre | 1,240.44 mi (1,996.29 km) |
| Isernia to Santo Tirso | 1,172.33 mi (1,886.68 km) |
| Isernia to Sao Bras de Alportel | 1,217.21 mi (1,958.90 km) |
| Isernia to Sao Felix da Marinha | 1,183.58 mi (1,904.79 km) |
| Isernia to Sao Joao da Madeira | 1,178.28 mi (1,896.25 km) |
| Isernia to Sao Joao de Ver | 1,180.80 mi (1,900.32 km) |
| Isernia to Sao Mamede de Infesta | 1,180.57 mi (1,899.94 km) |
| Isernia to Sao Pedro do Sul | 1,158.32 mi (1,864.14 km) |
| Isernia to Satao | 1,141.35 mi (1,836.83 km) |
| Isernia to Seia | 1,143.78 mi (1,840.73 km) |
| Isernia to Senhora da Hora | 1,183.34 mi (1,904.40 km) |
| Isernia to Serpa | 1,183.51 mi (1,904.67 km) |
| Isernia to Serta | 1,173.47 mi (1,888.52 km) |
| Isernia to Sesimbra | 1,250.05 mi (2,011.76 km) |
