| Isernia to Setubal | 1,237.70 mi (1,991.89 km) |
| Isernia to Sever do Vouga | 1,173.98 mi (1,889.34 km) |
| Isernia to Silves | 1,244.77 mi (2,003.26 km) |
| Isernia to Sines | 1,248.46 mi (2,009.20 km) |
| Isernia to Sintra | 1,257.81 mi (2,024.24 km) |
| Isernia to Sobrado de Paiva | 1,165.27 mi (1,875.33 km) |
| Isernia to Sobral de Monte Agraco | 1,241.41 mi (1,997.86 km) |
| Isernia to Soure | 1,197.13 mi (1,926.60 km) |
| Isernia to Tabua | 1,161.48 mi (1,869.22 km) |
| Isernia to Tavira | 1,206.10 mi (1,941.03 km) |
| Isernia to Tomar | 1,193.09 mi (1,920.10 km) |
| Isernia to Tondela | 1,162.16 mi (1,870.31 km) |
| Isernia to Torre de Moncorvo | 1,105.20 mi (1,778.65 km) |
| Isernia to Torres Novas | 1,201.38 mi (1,933.43 km) |
| Isernia to Torres Vedras | 1,246.12 mi (2,005.43 km) |
