| Isernia to Sangeorz-Bai | 649.92 mi (1,045.94 km) |
| Isernia to Sannicolau Mare | 442.31 mi (711.83 km) |
| Isernia to Santana | 487.37 mi (784.35 km) |
| Isernia to Satu Mare | 601.99 mi (968.81 km) |
| Isernia to Scobinti | 740.84 mi (1,192.26 km) |
| Isernia to Scornicesti | 558.70 mi (899.14 km) |
| Isernia to Sebes | 553.75 mi (891.18 km) |
| Isernia to Seini | 613.87 mi (987.93 km) |
| Isernia to Sfantu-Gheorghe | 646.47 mi (1,040.40 km) |
| Isernia to Sibiu | 572.96 mi (922.10 km) |
| Isernia to Sighetu Marmatiei | 643.50 mi (1,035.61 km) |
| Isernia to Sighisoara | 613.64 mi (987.55 km) |
| Isernia to Simeria | 526.66 mi (847.57 km) |
| Isernia to Sinaia | 622.71 mi (1,002.16 km) |
| Isernia to Slatina | 547.03 mi (880.36 km) |
