| Isernia to Ruzomberok | 571.86 mi (920.32 km) |
| Isernia to Sabinov | 615.26 mi (990.16 km) |
| Isernia to Sal'a | 486.04 mi (782.21 km) |
| Isernia to Samorin | 468.59 mi (754.12 km) |
| Isernia to Senec | 482.46 mi (776.44 km) |
| Isernia to Senica | 512.10 mi (824.15 km) |
| Isernia to Sered' | 492.35 mi (792.37 km) |
| Isernia to Skalica | 520.78 mi (838.11 km) |
| Isernia to Smizany | 592.48 mi (953.50 km) |
| Isernia to Snina | 638.35 mi (1,027.33 km) |
| Isernia to Spisska Nova Ves | 592.76 mi (953.95 km) |
| Isernia to Stara L'ubovna | 616.66 mi (992.42 km) |
| Isernia to Stara Tura | 523.32 mi (842.20 km) |
| Isernia to Stropkov | 635.85 mi (1,023.30 km) |
| Isernia to Stupava | 480.69 mi (773.60 km) |
