| Isla Vista to Southern Pines (North Carolina) | 2,279.87 mi (3,669.10 km) |
| Isla Vista to Southfield (Michigan) | 2,040.09 mi (3,283.21 km) |
| Isla Vista to Southgate (Michigan) | 2,041.81 mi (3,285.98 km) |
| Isla Vista to Southlake (Texas) | 1,306.89 mi (2,103.23 km) |
| Isla Vista to Spanaway (Washington) | 886.52 mi (1,426.71 km) |
| Isla Vista to Spanish Fork (Utah) | 598.94 mi (963.90 km) |
| Isla Vista to Spanish Lake (Missouri) | 1,664.84 mi (2,679.30 km) |
| Isla Vista to Spanish Springs (Nevada) | 362.48 mi (583.35 km) |
| Isla Vista to Sparks (Nevada) | 356.67 mi (574.00 km) |
| Isla Vista to Spartanburg (South Carolina) | 2,142.70 mi (3,448.35 km) |
| Isla Vista to Spearfish (South Dakota) | 1,100.02 mi (1,770.31 km) |
| Isla Vista to Speedway (Indiana) | 1,877.72 mi (3,021.89 km) |
| Isla Vista to Spencer (Iowa) | 1,454.07 mi (2,340.10 km) |
| Isla Vista to Spokane (Washington) | 924.36 mi (1,487.61 km) |
| Isla Vista to Spokane Valley (Washington) | 925.50 mi (1,489.45 km) |
