| Ispica to Resana | 630.29 mi (1,014.35 km) |
| Ispica to Rescaldina | 683.75 mi (1,100.39 km) |
| Ispica to Rezzato | 648.41 mi (1,043.52 km) |
| Ispica to Rho | 676.76 mi (1,089.14 km) |
| Ispica to Ribera | 102.75 mi (165.35 km) |
| Ispica to Riccione Marina | 512.43 mi (824.68 km) |
| Ispica to Riesi | 56.77 mi (91.36 km) |
| Ispica to Rieti | 403.29 mi (649.04 km) |
| Ispica to Rignano Flaminio | 395.77 mi (636.93 km) |
| Ispica to Rignano sull'Arno | 512.74 mi (825.18 km) |
| Ispica to Rimini | 517.41 mi (832.69 km) |
| Ispica to Rionero in Vulture | 288.55 mi (464.38 km) |
| Ispica to Riposto | 67.68 mi (108.92 km) |
| Ispica to Riva del Garda | 662.69 mi (1,066.50 km) |
| Ispica to Rivalta di Torino | 687.48 mi (1,106.39 km) |
