| Ispica to Santeramo in Colle | 295.15 mi (475.00 km) |
| Ispica to Santo Stefano di Magra | 572.96 mi (922.08 km) |
| Ispica to Santo Stino di Livenza | 628.94 mi (1,012.18 km) |
| Ispica to Sarezzo | 659.22 mi (1,060.92 km) |
| Ispica to Sarno | 279.10 mi (449.16 km) |
| Ispica to Saronno | 682.27 mi (1,098.00 km) |
| Ispica to Sarzana | 568.92 mi (915.59 km) |
| Ispica to Sassari | 436.78 mi (702.93 km) |
| Ispica to Sasso Marconi | 559.86 mi (901.02 km) |
| Ispica to Sassuolo | 578.23 mi (930.57 km) |
| Ispica to Sava | 288.40 mi (464.13 km) |
| Ispica to Saviano | 286.33 mi (460.81 km) |
| Ispica to Savigliano | 662.90 mi (1,066.83 km) |
| Ispica to Savignano sul Panaro | 569.16 mi (915.98 km) |
| Ispica to Savignano sul Rubicone | 521.57 mi (839.39 km) |
