| Ispica to Selvazzano Dentro | 615.84 mi (991.10 km) |
| Ispica to Senago | 677.49 mi (1,090.32 km) |
| Ispica to Senigallia | 486.92 mi (783.61 km) |
| Ispica to Seravezza | 555.58 mi (894.12 km) |
| Ispica to Seregno | 680.05 mi (1,094.43 km) |
| Ispica to Seriate | 671.01 mi (1,079.89 km) |
| Ispica to Sermoneta | 344.95 mi (555.15 km) |
| Ispica to Serramanna | 372.59 mi (599.62 km) |
| Ispica to Serravalle Pistoiese | 536.15 mi (862.85 km) |
| Ispica to Sessa Aurunca | 311.81 mi (501.81 km) |
| Ispica to Sesto Calende | 698.27 mi (1,123.76 km) |
| Ispica to Sesto Fiorentino | 524.52 mi (844.13 km) |
| Ispica to Sesto San Giovanni | 672.17 mi (1,081.75 km) |
| Ispica to Sestri Levante | 592.49 mi (953.52 km) |
| Ispica to Sestu | 360.60 mi (580.34 km) |
