| Ispica to Somma Lombardo | 693.68 mi (1,116.37 km) |
| Ispica to Somma Vesuviana | 283.63 mi (456.46 km) |
| Ispica to Sommacampagna | 631.38 mi (1,016.11 km) |
| Ispica to Sona | 633.82 mi (1,020.03 km) |
| Ispica to Sondrio | 698.48 mi (1,124.10 km) |
| Ispica to Sora | 347.70 mi (559.57 km) |
| Ispica to Sorbolo | 603.52 mi (971.28 km) |
| Ispica to Soresina | 643.29 mi (1,035.27 km) |
| Ispica to Sorisole | 675.58 mi (1,087.24 km) |
| Ispica to Sorrento | 267.14 mi (429.92 km) |
| Ispica to Sorso | 438.99 mi (706.49 km) |
| Ispica to Sortino | 27.49 mi (44.25 km) |
| Ispica to Soverato Marina | 159.25 mi (256.29 km) |
| Ispica to Sovicille | 489.07 mi (787.09 km) |
| Ispica to Spello | 444.69 mi (715.66 km) |
