| Ispica to Setubal | 1,303.41 mi (2,097.63 km) |
| Ispica to Sever do Vouga | 1,278.90 mi (2,058.19 km) |
| Ispica to Silves | 1,285.14 mi (2,068.24 km) |
| Ispica to Sines | 1,303.91 mi (2,098.44 km) |
| Ispica to Sintra | 1,329.52 mi (2,139.65 km) |
| Ispica to Sobrado de Paiva | 1,275.59 mi (2,052.87 km) |
| Ispica to Sobral de Monte Agraco | 1,316.49 mi (2,118.69 km) |
| Ispica to Soure | 1,289.90 mi (2,075.89 km) |
| Ispica to Tabua | 1,259.27 mi (2,026.61 km) |
| Ispica to Tavira | 1,242.41 mi (1,999.47 km) |
| Ispica to Tomar | 1,277.36 mi (2,055.71 km) |
| Ispica to Tondela | 1,262.89 mi (2,032.43 km) |
| Ispica to Torre de Moncorvo | 1,218.29 mi (1,960.64 km) |
| Ispica to Torres Novas | 1,283.39 mi (2,065.42 km) |
| Ispica to Torres Vedras | 1,322.59 mi (2,128.50 km) |
