| Ispica to Sangeorz-Bai | 885.36 mi (1,424.85 km) |
| Ispica to Sannicolau Mare | 705.74 mi (1,135.78 km) |
| Ispica to Santana | 743.21 mi (1,196.07 km) |
| Ispica to Satu Mare | 862.11 mi (1,387.42 km) |
| Ispica to Scobinti | 955.39 mi (1,537.55 km) |
| Ispica to Scornicesti | 737.31 mi (1,186.58 km) |
| Ispica to Sebes | 776.21 mi (1,249.18 km) |
| Ispica to Seini | 869.28 mi (1,398.97 km) |
| Ispica to Sfantu-Gheorghe | 842.69 mi (1,356.18 km) |
| Ispica to Sibiu | 785.13 mi (1,263.54 km) |
| Ispica to Sighetu Marmatiei | 895.15 mi (1,440.60 km) |
| Ispica to Sighisoara | 827.38 mi (1,331.53 km) |
| Ispica to Simeria | 753.79 mi (1,213.11 km) |
| Ispica to Sinaia | 809.91 mi (1,303.42 km) |
| Ispica to Slatina | 723.99 mi (1,165.16 km) |
