| Ispica to Santander | 1,087.44 mi (1,750.07 km) |
| Ispica to Santany | 663.94 mi (1,068.52 km) |
| Ispica to Santiago de Compostela | 1,308.17 mi (2,105.29 km) |
| Ispica to Santiago del Teide | 1,927.88 mi (3,102.62 km) |
| Ispica to Santiponce | 1,152.50 mi (1,854.77 km) |
| Ispica to Santomera | 878.52 mi (1,413.84 km) |
| Ispica to Santona | 1,070.48 mi (1,722.77 km) |
| Ispica to Santurce-Antiguo | 1,047.75 mi (1,686.19 km) |
| Ispica to Sarria | 1,250.86 mi (2,013.06 km) |
| Ispica to Sauzal | 1,901.61 mi (3,060.35 km) |
| Ispica to Sedavi | 849.72 mi (1,367.50 km) |
| Ispica to Segorbe | 859.57 mi (1,383.34 km) |
| Ispica to Segovia | 1,060.40 mi (1,706.55 km) |
| Ispica to Senmanat | 759.40 mi (1,222.14 km) |
| Ispica to Sesena | 1,030.19 mi (1,657.92 km) |
