| Issoire to Reims | 259.54 mi (417.69 km) |
| Issoire to Rennes | 292.85 mi (471.29 km) |
| Issoire to Revel | 156.61 mi (252.03 km) |
| Issoire to Reze | 256.31 mi (412.49 km) |
| Issoire to Riedisheim | 247.62 mi (398.51 km) |
| Issoire to Rillieux-la-Pape | 81.89 mi (131.78 km) |
| Issoire to Riom | 25.02 mi (40.27 km) |
| Issoire to Riorges | 51.39 mi (82.71 km) |
| Issoire to Ris-Orangis | 218.38 mi (351.45 km) |
| Issoire to Rive-de-Gier | 66.21 mi (106.56 km) |
| Issoire to Rivesaltes | 192.65 mi (310.04 km) |
| Issoire to Rixheim | 249.04 mi (400.78 km) |
| Issoire to Roanne | 52.14 mi (83.91 km) |
| Issoire to Roche-la-Moliere | 52.61 mi (84.67 km) |
| Issoire to Rochefort | 204.72 mi (329.46 km) |
