| Issum to Santeramo in Colle | 889.98 mi (1,432.29 km) |
| Issum to Santo Stefano di Magra | 534.59 mi (860.34 km) |
| Issum to Santo Stino di Livenza | 492.15 mi (792.03 km) |
| Issum to Sarezzo | 441.82 mi (711.03 km) |
| Issum to Sarno | 836.91 mi (1,346.88 km) |
| Issum to Saronno | 425.61 mi (684.95 km) |
| Issum to Sarzana | 538.46 mi (866.57 km) |
| Issum to Sassari | 753.93 mi (1,213.33 km) |
| Issum to Sasso Marconi | 541.13 mi (870.87 km) |
| Issum to Sassuolo | 522.89 mi (841.51 km) |
| Issum to Sava | 935.08 mi (1,504.86 km) |
| Issum to Saviano | 828.45 mi (1,333.25 km) |
| Issum to Savigliano | 479.22 mi (771.23 km) |
| Issum to Savignano sul Panaro | 531.76 mi (855.78 km) |
| Issum to Savignano sul Rubicone | 584.12 mi (940.06 km) |
