| Issum to Savona | 508.55 mi (818.43 km) |
| Issum to Scafati | 838.87 mi (1,350.02 km) |
| Issum to Scalea | 926.10 mi (1,490.42 km) |
| Issum to Scandiano | 518.54 mi (834.51 km) |
| Issum to Scandicci | 581.50 mi (935.83 km) |
| Issum to Schio | 461.13 mi (742.12 km) |
| Issum to Sciacca | 1,022.39 mi (1,645.38 km) |
| Issum to Scicli | 1,096.78 mi (1,765.09 km) |
| Issum to Scordia | 1,066.39 mi (1,716.19 km) |
| Issum to Scorze | 487.08 mi (783.88 km) |
| Issum to Sedico | 454.69 mi (731.75 km) |
| Issum to Sedriano | 434.22 mi (698.81 km) |
| Issum to Segni | 748.68 mi (1,204.88 km) |
| Issum to Segrate | 438.03 mi (704.94 km) |
| Issum to Selargius | 858.99 mi (1,382.41 km) |
