| Issum to Smolyan | 1,102.45 mi (1,774.23 km) |
| Issum to Sofia | 998.35 mi (1,606.69 km) |
| Issum to Sopot | 1,053.68 mi (1,695.73 km) |
| Issum to Sozopol | 1,177.97 mi (1,895.75 km) |
| Issum to Sredets | 1,161.37 mi (1,869.04 km) |
| Issum to Stamboliyski | 1,069.81 mi (1,721.69 km) |
| Issum to Stara Zagora | 1,097.82 mi (1,766.77 km) |
| Issum to Svilengrad | 1,149.63 mi (1,850.15 km) |
| Issum to Svishtov | 1,033.56 mi (1,663.35 km) |
| Issum to Targovishte | 1,097.75 mi (1,766.66 km) |
| Issum to Teteven | 1,023.13 mi (1,646.56 km) |
| Issum to Troyan | 1,041.70 mi (1,676.45 km) |
| Issum to Tryavna | 1,072.39 mi (1,725.85 km) |
| Issum to Tutrakan | 1,065.57 mi (1,714.87 km) |
| Issum to Varna | 1,152.11 mi (1,854.14 km) |
