| Issum to Castelo Branco | 1,048.85 mi (1,687.97 km) |
| Issum to Castro Daire | 1,002.16 mi (1,612.82 km) |
| Issum to Celorico de Basto | 978.25 mi (1,574.34 km) |
| Issum to Chamusca | 1,105.38 mi (1,778.93 km) |
| Issum to Chaves | 941.84 mi (1,515.74 km) |
| Issum to Cinfaes | 997.81 mi (1,605.83 km) |
| Issum to Coimbra | 1,055.75 mi (1,699.07 km) |
| Issum to Condeixa-a-Nova | 1,063.21 mi (1,711.07 km) |
| Issum to Corroios | 1,167.56 mi (1,879.00 km) |
| Issum to Coruche | 1,128.93 mi (1,816.84 km) |
| Issum to Costa de Caparica | 1,168.50 mi (1,880.52 km) |
| Issum to Covilha | 1,022.56 mi (1,645.65 km) |
| Issum to Eiras | 1,053.88 mi (1,696.06 km) |
| Issum to Elvas | 1,093.17 mi (1,759.29 km) |
| Issum to Entroncamento | 1,098.43 mi (1,767.75 km) |
