| Issum to Setubal | 1,164.73 mi (1,874.45 km) |
| Issum to Sever do Vouga | 1,025.22 mi (1,649.93 km) |
| Issum to Silves | 1,228.77 mi (1,977.52 km) |
| Issum to Sines | 1,196.51 mi (1,925.60 km) |
| Issum to Sintra | 1,164.59 mi (1,874.22 km) |
| Issum to Sobrado de Paiva | 1,005.76 mi (1,618.62 km) |
| Issum to Sobral de Monte Agraco | 1,144.90 mi (1,842.53 km) |
| Issum to Soure | 1,071.14 mi (1,723.83 km) |
| Issum to Tabua | 1,034.82 mi (1,665.38 km) |
| Issum to Tavira | 1,210.68 mi (1,948.40 km) |
| Issum to Tomar | 1,089.28 mi (1,753.02 km) |
| Issum to Tondela | 1,027.92 mi (1,654.28 km) |
| Issum to Torre de Moncorvo | 960.27 mi (1,545.41 km) |
| Issum to Torres Novas | 1,100.38 mi (1,770.89 km) |
| Issum to Torres Vedras | 1,144.86 mi (1,842.48 km) |
