| Issum to Sabinanigo | 699.73 mi (1,126.11 km) |
| Issum to Sagunto | 880.31 mi (1,416.72 km) |
| Issum to Salamanca | 928.76 mi (1,494.69 km) |
| Issum to Salobrena | 1,133.74 mi (1,824.57 km) |
| Issum to Salou | 765.02 mi (1,231.18 km) |
| Issum to Salt | 682.54 mi (1,098.45 km) |
| Issum to Salvatierra de Mino | 958.31 mi (1,542.25 km) |
| Issum to Sama | 800.78 mi (1,288.73 km) |
| Issum to San Adrian de Besos | 726.20 mi (1,168.70 km) |
| Issum to San Agustin de Guadalix | 889.44 mi (1,431.41 km) |
| Issum to San Andres de la Barca | 728.25 mi (1,172.01 km) |
| Issum to San Andres de Llevaneras | 713.28 mi (1,147.92 km) |
| Issum to San Andres del Rabanedo | 834.61 mi (1,343.17 km) |
| Issum to San Bartolome | 1,990.23 mi (3,202.96 km) |
| Issum to San Baudilio de Llobregat | 734.18 mi (1,181.55 km) |
