| Issum to Santander | 732.99 mi (1,179.63 km) |
| Issum to Santany | 856.67 mi (1,378.67 km) |
| Issum to Santiago de Compostela | 919.76 mi (1,480.21 km) |
| Issum to Santiago del Teide | 2,005.44 mi (3,227.44 km) |
| Issum to Santiponce | 1,148.49 mi (1,848.31 km) |
| Issum to Santomera | 999.39 mi (1,608.36 km) |
| Issum to Santona | 723.83 mi (1,164.90 km) |
| Issum to Santurce-Antiguo | 717.76 mi (1,155.12 km) |
| Issum to Sarria | 885.40 mi (1,424.91 km) |
| Issum to Sauzal | 1,982.83 mi (3,191.06 km) |
| Issum to Sedavi | 898.53 mi (1,446.05 km) |
| Issum to Segorbe | 872.74 mi (1,404.54 km) |
| Issum to Segovia | 886.43 mi (1,426.56 km) |
| Issum to Senmanat | 715.38 mi (1,151.29 km) |
| Issum to Sesena | 926.38 mi (1,490.86 km) |
