| Issum to Trujillo | 1,022.12 mi (1,644.94 km) |
| Issum to Tudela | 755.73 mi (1,216.23 km) |
| Issum to Tudela de Duero | 861.92 mi (1,387.12 km) |
| Issum to Tuineje | 1,922.37 mi (3,093.75 km) |
| Issum to Ubeda | 1,048.73 mi (1,687.77 km) |
| Issum to Ubrique | 1,180.02 mi (1,899.06 km) |
| Issum to Umbrete | 1,155.42 mi (1,859.47 km) |
| Issum to Utebo | 763.73 mi (1,229.10 km) |
| Issum to Utiel | 904.62 mi (1,455.85 km) |
| Issum to Utrera | 1,156.92 mi (1,861.88 km) |
| Issum to Valdemorillo | 911.70 mi (1,467.24 km) |
| Issum to Valdemoro | 920.47 mi (1,481.35 km) |
| Issum to Valdepenas | 1,001.88 mi (1,612.37 km) |
| Issum to Valencia | 895.58 mi (1,441.30 km) |
| Issum to Valladolid | 862.07 mi (1,387.37 km) |
