| Issum to Emeryville (California) | 5,529.67 mi (8,899.14 km) |
| Issum to Emmaus (Pennsylvania) | 3,791.63 mi (6,102.04 km) |
| Issum to Emporia (Kansas) | 4,675.55 mi (7,524.57 km) |
| Issum to Encinitas (California) | 5,670.81 mi (9,126.29 km) |
| Issum to Endicott (New York) | 3,743.27 mi (6,024.21 km) |
| Issum to Endwell (New York) | 3,740.71 mi (6,020.10 km) |
| Issum to Englewood (Colorado) | 4,909.14 mi (7,900.49 km) |
| Issum to Englewood (Florida) | 4,730.83 mi (7,613.54 km) |
| Issum to Englewood (New Jersey) | 3,715.13 mi (5,978.92 km) |
| Issum to Englewood (Ohio) | 4,164.71 mi (6,702.46 km) |
| Issum to Enid (Oklahoma) | 4,840.22 mi (7,789.59 km) |
| Issum to Ennis (Texas) | 5,012.38 mi (8,066.65 km) |
| Issum to Ensley (Florida) | 4,747.02 mi (7,639.60 km) |
| Issum to Enterprise (Alabama) | 4,649.24 mi (7,482.24 km) |
| Issum to Enterprise (Nevada) | 5,436.08 mi (8,748.52 km) |
