| Issum to Enumclaw (Washington) | 4,962.36 mi (7,986.15 km) |
| Issum to Ephrata (Pennsylvania) | 3,834.80 mi (6,171.52 km) |
| Issum to Erie (Colorado) | 4,889.13 mi (7,868.29 km) |
| Issum to Erie (Pennsylvania) | 3,897.18 mi (6,271.90 km) |
| Issum to Erlanger (Kentucky) | 4,216.66 mi (6,786.06 km) |
| Issum to Escanaba (Michigan) | 3,987.09 mi (6,416.61 km) |
| Issum to Escondido (California) | 5,660.05 mi (9,108.98 km) |
| Issum to Española (New Mexico) | 5,145.09 mi (8,280.23 km) |
| Issum to Essex (Maryland) | 3,885.73 mi (6,253.48 km) |
| Issum to Essex Junction (Vermont) | 3,523.81 mi (5,671.03 km) |
| Issum to Estelle (Louisiana) | 4,893.92 mi (7,876.00 km) |
| Issum to Estero (Florida) | 4,735.81 mi (7,621.55 km) |
| Issum to Euclid (Ohio) | 3,976.72 mi (6,399.92 km) |
| Issum to Eufaula (Alabama) | 4,591.90 mi (7,389.95 km) |
| Issum to Eugene (Oregon) | 5,177.47 mi (8,332.33 km) |
