| Issum to Olympia Heights (Florida) | 4,711.56 mi (7,582.52 km) |
| Issum to Omaha (Nebraska) | 4,522.49 mi (7,278.24 km) |
| Issum to On Top of the World Designated Place (Florida) | 4,618.98 mi (7,433.54 km) |
| Issum to Onalaska (Wisconsin) | 4,221.46 mi (6,793.78 km) |
| Issum to Oneida (New York) | 3,684.04 mi (5,928.88 km) |
| Issum to Oneonta (New York) | 3,688.41 mi (5,935.92 km) |
| Issum to Ontario (California) | 5,622.84 mi (9,049.09 km) |
| Issum to Ontario (Oregon) | 5,020.45 mi (8,079.64 km) |
| Issum to Opa-locka (Florida) | 4,699.05 mi (7,562.39 km) |
| Issum to Opelika (Alabama) | 4,562.80 mi (7,343.12 km) |
| Issum to Opelousas (Louisiana) | 4,935.29 mi (7,942.58 km) |
| Issum to Orange (California) | 5,643.16 mi (9,081.79 km) |
| Issum to Orange (Texas) | 5,021.15 mi (8,080.76 km) |
| Issum to Orange City (Florida) | 4,586.82 mi (7,381.77 km) |
| Issum to Orangeburg (South Carolina) | 4,341.19 mi (6,986.46 km) |
