| Issum to Seymour (Tennessee) | 4,338.46 mi (6,982.08 km) |
| Issum to Shady Hills (Florida) | 4,665.40 mi (7,508.23 km) |
| Issum to Shafter (California) | 5,584.44 mi (8,987.29 km) |
| Issum to Shaker Heights (Ohio) | 3,983.31 mi (6,410.53 km) |
| Issum to Shakopee (Minnesota) | 4,256.33 mi (6,849.90 km) |
| Issum to Sharon (Pennsylvania) | 3,954.40 mi (6,363.99 km) |
| Issum to Sharonville (Ohio) | 4,196.64 mi (6,753.85 km) |
| Issum to Shasta Lake (California) | 5,361.29 mi (8,628.16 km) |
| Issum to Shawnee (Kansas) | 4,594.40 mi (7,393.97 km) |
| Issum to Shawnee (Oklahoma) | 4,863.50 mi (7,827.05 km) |
| Issum to Sheboygan (Wisconsin) | 4,105.16 mi (6,606.62 km) |
| Issum to Shelby (North Carolina) | 4,279.76 mi (6,887.61 km) |
| Issum to Shelbyville (Indiana) | 4,236.42 mi (6,817.86 km) |
| Issum to Shelbyville (Kentucky) | 4,280.48 mi (6,888.77 km) |
| Issum to Shelbyville (Tennessee) | 4,461.86 mi (7,180.67 km) |
