| Issum to Smyrna (Delaware) | 3,852.86 mi (6,200.58 km) |
| Issum to Smyrna (Georgia) | 4,468.23 mi (7,190.92 km) |
| Issum to Smyrna (Tennessee) | 4,441.20 mi (7,147.42 km) |
| Issum to Snellville (Georgia) | 4,448.31 mi (7,158.86 km) |
| Issum to Snoqualmie (Washington) | 4,939.38 mi (7,949.16 km) |
| Issum to Snyder (Texas) | 5,147.42 mi (8,283.97 km) |
| Issum to Socastee (South Carolina) | 4,256.57 mi (6,850.29 km) |
| Issum to Socorro (Texas) | 5,394.88 mi (8,682.21 km) |
| Issum to Soddy-Daisy (Tennessee) | 4,424.30 mi (7,120.22 km) |
| Issum to Solana Beach (California) | 5,673.94 mi (9,131.32 km) |
| Issum to Soledad (California) | 5,587.46 mi (8,992.15 km) |
| Issum to Solon (Ohio) | 3,983.25 mi (6,410.42 km) |
| Issum to Somers Point (New Jersey) | 3,811.80 mi (6,134.50 km) |
| Issum to Somerset (Kentucky) | 4,311.89 mi (6,939.32 km) |
| Issum to Somerset (New Jersey) | 3,753.35 mi (6,040.43 km) |
