| Issum to Southern Pines (North Carolina) | 4,199.03 mi (6,757.69 km) |
| Issum to Southfield (Michigan) | 4,000.96 mi (6,438.93 km) |
| Issum to Southgate (Michigan) | 4,011.67 mi (6,456.16 km) |
| Issum to Southlake (Texas) | 4,997.84 mi (8,043.25 km) |
| Issum to Spanaway (Washington) | 4,978.94 mi (8,012.84 km) |
| Issum to Spanish Fork (Utah) | 5,092.13 mi (8,194.99 km) |
| Issum to Spanish Lake (Missouri) | 4,438.83 mi (7,143.60 km) |
| Issum to Spanish Springs (Nevada) | 5,349.91 mi (8,609.84 km) |
| Issum to Sparks (Nevada) | 5,356.11 mi (8,619.83 km) |
| Issum to Spartanburg (South Carolina) | 4,311.87 mi (6,939.29 km) |
| Issum to Spearfish (South Dakota) | 4,609.79 mi (7,418.74 km) |
| Issum to Speedway (Indiana) | 4,241.47 mi (6,825.98 km) |
| Issum to Spencer (Iowa) | 4,395.28 mi (7,073.53 km) |
| Issum to Spokane (Washington) | 4,821.89 mi (7,760.08 km) |
| Issum to Spokane Valley (Washington) | 4,817.06 mi (7,752.31 km) |
