| Karlovy Vary to Siegburg | 252.06 mi (405.65 km) |
| Karlovy Vary to Siegen | 217.82 mi (350.55 km) |
| Karlovy Vary to Sigmaringen | 221.84 mi (357.01 km) |
| Karlovy Vary to Simbach am Inn | 135.85 mi (218.63 km) |
| Karlovy Vary to Simmerath | 290.41 mi (467.37 km) |
| Karlovy Vary to Sindelfingen | 202.88 mi (326.51 km) |
| Karlovy Vary to Sinsheim | 190.55 mi (306.65 km) |
| Karlovy Vary to Sinzheim | 234.23 mi (376.95 km) |
| Karlovy Vary to Sinzig | 248.50 mi (399.92 km) |
| Karlovy Vary to Soest | 227.23 mi (365.69 km) |
| Karlovy Vary to Solingen | 261.40 mi (420.69 km) |
| Karlovy Vary to Soltau | 230.56 mi (371.06 km) |
| Karlovy Vary to Sommerda | 100.21 mi (161.27 km) |
| Karlovy Vary to Sondershausen | 117.61 mi (189.28 km) |
| Karlovy Vary to Sonneberg | 75.75 mi (121.91 km) |
