| Karlovy Vary to Sangeorz-Bai | 571.80 mi (920.22 km) |
| Karlovy Vary to Sannicolau Mare | 458.08 mi (737.21 km) |
| Karlovy Vary to Santana | 478.27 mi (769.71 km) |
| Karlovy Vary to Satu Mare | 483.83 mi (778.65 km) |
| Karlovy Vary to Scobinti | 668.21 mi (1,075.39 km) |
| Karlovy Vary to Scornicesti | 670.49 mi (1,079.05 km) |
| Karlovy Vary to Sebes | 574.32 mi (924.27 km) |
| Karlovy Vary to Seini | 501.79 mi (807.55 km) |
| Karlovy Vary to Sfantu-Gheorghe | 667.28 mi (1,073.88 km) |
| Karlovy Vary to Sibiu | 603.91 mi (971.90 km) |
| Karlovy Vary to Sighetu Marmatiei | 522.90 mi (841.53 km) |
| Karlovy Vary to Sighisoara | 613.77 mi (987.77 km) |
| Karlovy Vary to Simeria | 556.87 mi (896.20 km) |
| Karlovy Vary to Sinaia | 677.03 mi (1,089.57 km) |
| Karlovy Vary to Slatina | 669.78 mi (1,077.90 km) |
