| Karlovy Vary to Ruzomberok | 298.57 mi (480.50 km) |
| Karlovy Vary to Sabinov | 375.19 mi (603.81 km) |
| Karlovy Vary to Sal'a | 267.75 mi (430.90 km) |
| Karlovy Vary to Samorin | 251.86 mi (405.33 km) |
| Karlovy Vary to Senec | 247.02 mi (397.54 km) |
| Karlovy Vary to Senica | 228.45 mi (367.65 km) |
| Karlovy Vary to Sered' | 256.84 mi (413.35 km) |
| Karlovy Vary to Skalica | 217.49 mi (350.01 km) |
| Karlovy Vary to Smizany | 353.88 mi (569.51 km) |
| Karlovy Vary to Snina | 424.15 mi (682.60 km) |
| Karlovy Vary to Spisska Nova Ves | 355.78 mi (572.57 km) |
| Karlovy Vary to Stara L'ubovna | 353.95 mi (569.63 km) |
| Karlovy Vary to Stara Tura | 238.55 mi (383.90 km) |
| Karlovy Vary to Stropkov | 398.28 mi (640.97 km) |
| Karlovy Vary to Stupava | 231.13 mi (371.97 km) |
