| Karlsruhe to Coswig | 266.12 mi (428.28 km) |
| Karlsruhe to Cottbus | 322.94 mi (519.72 km) |
| Karlsruhe to Crailsheim | 75.93 mi (122.20 km) |
| Karlsruhe to Cremlingen | 244.57 mi (393.60 km) |
| Karlsruhe to Crimmitschau | 216.82 mi (348.94 km) |
| Karlsruhe to Cuxhaven | 335.47 mi (539.88 km) |
| Karlsruhe to Dachau | 147.71 mi (237.71 km) |
| Karlsruhe to Dallgow-Doberitz | 316.88 mi (509.96 km) |
| Karlsruhe to Damme | 242.79 mi (390.74 km) |
| Karlsruhe to Darmstadt | 60.67 mi (97.63 km) |
| Karlsruhe to Dassel | 201.18 mi (323.77 km) |
| Karlsruhe to Datteln | 188.64 mi (303.58 km) |
| Karlsruhe to Dautphe | 127.93 mi (205.88 km) |
| Karlsruhe to Deggendorf | 207.48 mi (333.90 km) |
| Karlsruhe to Delbruck | 190.66 mi (306.84 km) |
