| Karlsruhe to Obernburg am Main | 66.28 mi (106.67 km) |
| Karlsruhe to Obernkirchen | 227.21 mi (365.66 km) |
| Karlsruhe to Oberschleissheim | 153.64 mi (247.26 km) |
| Karlsruhe to Oberstdorf | 140.24 mi (225.69 km) |
| Karlsruhe to Obertraubling | 170.62 mi (274.59 km) |
| Karlsruhe to Obertshausen | 75.56 mi (121.60 km) |
| Karlsruhe to Oberursel | 82.87 mi (133.36 km) |
| Karlsruhe to Ochsenfurt | 86.98 mi (139.98 km) |
| Karlsruhe to Ochsenhausen | 95.81 mi (154.20 km) |
| Karlsruhe to Ochtrup | 227.16 mi (365.58 km) |
| Karlsruhe to Odenthal | 151.07 mi (243.12 km) |
| Karlsruhe to Oelde | 195.45 mi (314.54 km) |
| Karlsruhe to Oelsnitz | 194.17 mi (312.49 km) |
| Karlsruhe to Oer-Erkenschwick | 188.89 mi (304.00 km) |
| Karlsruhe to Oerlinghausen | 204.67 mi (329.38 km) |
